Nov. 29, 2021
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#Omicron #COVID19variant #coronavirusvariant Dr. Andre Campbell, Professor of Surgery of UCSF and Trauma Surgeon Zuckerberg San Francisco General Hospital, joins Yahoo Finance's Karina Mitchell to discuss what we know about the Omicron COVID-19 variant. Don't Miss: Valley of Hype: The Culture That Built Elizabeth Holmes WATCH HERE: https://youtu.be/Sb179GLPNYE
Nov. 29, 2021
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Pfizer Inc. Chief Executive Officer Albert Bourla spoke about the pharmaceutical company's efforts to combat the omicron variant through its vaccine and antiviral pill on with David Westin on "Balance of Power."
Albert Bourla (Greek: Άλμπερτ Μπουρλά, born October 21, 1961) is a Greek-American veterinarian and the chairman and chief executive officer of Pfizer, an American pharmaceutical company. He joined the company in 1993 and has held several executive roles across Pfizer's divisions. Prior to becoming chief executive officer, Bourla served as chief operating officer.
In addition to the boards of Pfizer and the Pfizer Foundation, he serves or has served on the boards of the Biotechnology Innovation Organization, Catalyst, the Partnership for New York City, and the Pharmaceutical Research and Manufacturers of America. Bourla is also a member of The Business Council and the Business Roundtable. He engages often with business leaders such as Bill Gates.[2]
Bourla was motivated by an early love for animals and medicine and is credited with reshaping Pfizer to be a company focused on research and development and branded patent-protected prescription drugs. He is also credited with helping the development of Improvac, which eradicates boar taint, and for refocusing Pfizer's vaccine division to focus on staphylococcus, clostridioides difficile infection, infant diseases, and the Pfizer–BioNTech COVID-19 vaccine. He opposes government interference in pharmaceutical pricing, which he believes would hamper spending on development of new drugs.[2]
Bourla was born and raised in Thessaloniki, Greece.[3] His parents, who were Sephardi Jews, were among the 2,000 of 50,000 Jews in Thessaloniki to survive the Holocaust; his mother was minutes away from execution by firing squad when she was spared via a ransom paid to a Nazi Party official by her non-Jewish brother-in-law, while his father happened to be out of the Jewish ghetto when the residents were taken to the Auschwitz concentration camp and went into hiding, never to see his parents again.[4][5]
Bourla joined Sephardic Heritage International in DC (SHIN-DC) on January 28, 2021, where he told his Greek Sephardic family's story of tragedy and survival at the organization's Annual Congressional Commemoration for International Holocaust Remembrance Day, alongside remarks from Her Excellency Alexandra Papadopoulou, Ambassador of Greece to the United States.
Bourla earned a doctorate in the biotechnology of reproduction at Aristotle University of Thessaloniki's Veterinary School in 1985.[2][6] He left Greece with his wife when he was 34 after a promotion within Pfizer and since then he has lived in seven different cities, in four different countries.[7]
GFS被设计为分布式水平扩展的文件系统，在便宜的x86服务器集群中提供自动容错能力，高并发读写的扩展性能力，设计源自于多年来的工作负载和技术环境积累，开始探寻不同于传统文件系统接口的设计，目前在google内部部署很多，使用广泛，被证明了是一个成功的存储系统，
介绍
性能、扩展性、可靠性、可用性是gfs设计基本准则，不同于传统文件的设计，启发来自于目前日新月异的工作负载和新的需求，总结出以下设计目标，第一，组件失效是经常发生的，不同于传统商业存储系统使用大量商用硬件保证可靠性，出错原因众多，比如磁盘，网络，电源，天灾人祸等等，因此系统需要做到监控，错误探查，自动恢复，容错；第二，文件很大，xGB大文件很多，同时每个文件包含众多doc，考虑到文件大小和访问模式，block size需要重新设计；第三，大多数文件写少读写，多数写一次然后多次读取，且读写都有模式，顺序读和追加写为最常见的模式；第四，重新设计文件api可以提供更好的灵活性，gfs简化了一致性模型的同时没有给应用开发带来负担，提供原子record append来保证并发写性能和一致性。目前的规模为1000s节点共计300TB存储空间，100s客户端并发访问。
设计参考
关键假设
open、close、read、write、snapshot、 record append
架构
chunk size
元数据
operator log
一致性模型
客户端编程
系统api交互
租约机制和全局修改顺序
copy on write的snapshot机制（文件或者目录级别），对chunk增加引用计数，首先回收所有租约，保证chunk有修改得时候会先找master请求获得租约，给master重新复制一份chunk创造时机；
master操作
master执行所有名字空间的请求，chunk的复制，决定新chunk创建位置，负载均衡，GC旧chunk等等
容错和诊断
用快速恢复和复制集来保障高可用
性能和经验
一开始gfs设计使用在生产环境，后来开发和实验环境也需要部署，生产环境支持相对容易，开发和实验环境，就需要整套的权限控制，quotas等等控制系统，支持的系统多了一周，发现了一些驱动和linux内核相关的错误。
相关工作和结论
通过对工作负载的观察，进行了很多针对性设计，record append以及顺序读，大文件而不是海量小文件，读多写少，数据和控制分离，master单点瓶颈通过精心设计来规避，最终在指定的负载下完成了水平扩展性，并具备容错恢复能力
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版权声明：本文为CSDN博主「WhateverYoung」的原创文章，遵循CC 4.0 BY-SA版权协议，转载请附上原文出处链接及本声明。
原文链接：https://blog.csdn.net/yangfeng2014/article/details/104102836
Nov. 20, 2021
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He's an American business magnate. He's best known for his involvement in the luxury casino and hotel industry. In 2015, Forbes estimated his net worth at US$2.4 billion. He's Steve Wynn and here are his Top 10 Rules for Success. * Join my BELIEVE newsletter: http://www.evancarmichael.com/newslet... 1. Love the process As his father had left $350,000 of gaming debts, he relinquished a position at Yale Law School to take charge of his family's business. 2. Don't be reckless He received his Bachelor of Arts in cultural anthropology at the University of Pennsylvania. 3. Raise people's self-esteem He worked the bingo parlors himself, and within a year he had expanded the company. 4. Try new ideas His success with his family's business allowed him to purchase a small stake in the Frontier Hotel and Casino. 5. Give the best guest experience He renovated, and expanded the Golden Nugget from a gambling hall to a resort hotel and casino with enormous success. 6. Be consistent In 1977 he opened the Golden Nugget's first hotel tower. Frank Sinatra was a periodic headliner at the Golden Nugget. 7. Love what you do His first major casino on the Las Vegas Strip was The Mirage, which opened in November 1989. 8. Help others In 2000, he sold his company Mirage Resorts to MGM Grand, resulting in the formation of MGM Mirage. 9. Stick to simple ideas Through Wynn Resorts he has overseen the construction and development of several luxury resorts. 10. Create a family He's an avid collector of fine art, often exhibiting pieces by artists such as Picasso and Claude Monet in Wynn Resorts' hotels. Source: https://youtu.be/6NA5vBVk1-8 https://youtu.be/eOesXyfJGI0 https://youtu.be/HJ_QsziXfqM https://youtu.be/6vPSI3IgySY https://youtu.be/AOcHhJCBzrg https://youtu.be/ef4p-XOsc4w https://youtu.be/MXFliOWeu6U
Cofounder, Wynn Resorts
REAL TIME NET WORTH
Nov. 28, 2021
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Steve Wynn, founder of Wynn Resorts, in the second part of his interview, discusses further his life as an entrepreneur, what he does to motivate his employees, and how he creates experiences that keep customers’ returning. Wynn also expresses his views on Obamacare, America’s fiscal policy, and the future of his business. “I take sides only on the issues that pertain to the health of my workforce,” explains Wynn. He has resorts in Las Vegas, Macau, China, and hopes to soon begin building another in Massachusetts. Watch part I here https://www.youtube.com/watch?v=m9Lg7.
Nov. 28, 2021
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Part I: Wynn Resorts owner Steve Wynn discusses his life, his dad's death, being broke, and how he got into the hotel and casino business. Wynn came to Las Vegas for a vacation, met Frank Sinatra, and fell in love with the city. Wynn's banker said, "Steve, this town needs young people. If you stay here you'll end up owning the place." Wynn stayed and enjoys running a successful hotel and casino business.
Nov. 16, 2021
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The U.S. is spearheading a coordinated release of crude oil reserves with China, Japan, India, and South Korea in a challenge to OPEC+. Bloomberg's Julian Lee examines what the move means for the global oil market.
艾伟德（Gladys Aylward，1902年2月24日－1970年1月3日）是一位原籍英国的独立女传教士，被称为“小妇人”，她在中国传教的经历在西方广为人知。
1902年2月24日，艾伟德生于英国伦敦以北米德尔塞克斯郡埃德蒙顿的一个工人阶级家庭，父亲是一名邮差。早年未受太多教育，做过侍女，后决心去中国传教，但是没有通过内地会的考试。1930年10月18日，她自英国只身出发，花费了所有的积蓄，乘船和火车，穿越苏联、途中几乎被拘留，后又取道日本，最终到达中国天津、北京，然后又长途跋涉到达山西阳城县，接替年老的卫理会传教士珍妮·劳生（Jeannie Lawson）。
在阳城，艾伟德创立了八福客栈[5][6][7]用于传教。她曾接受当地道尹的请求，帮助妇女放脚，还曾帮助平息当地监狱的骚乱，她还收养了很多孤儿。1936年艾伟德加入中国籍。
抗日战争爆发后，该地区被日军侵占，宣教团体保持中立，艾伟德厌恶日军暴行，帮助救治中国难民和伤员，并将日军行踪通知中国方面。1940年艾伟德率领94名儿童经过数十天艰苦的步行，安全转移到西安。后在陕西、甘肃、四川等地传教。
1949年回到英国家乡，英国广播公司的Alan Burgess将她的经历写成《小妇人》（The Small Woman）一书。1958年她决定重新回到中国大陆，但被拒绝入境，于是前往台湾，于北投（后迁木栅）创立了艾伟德儿童之家[8]（后改为伯大尼儿少家园）[9]。1970年1月3日，因流感并发肺炎，在台湾病逝，后葬于美国基督教效力会基督书院[8]。
英国埃德蒙顿的一间中学以她的名字命名（格拉蒂丝·艾伟德学校）。
Nov. 25, 2021
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Today’s investors enjoy the luxury of using fast internet connections and large amounts of information to track potential equity drivers and make fast, profitable transactions.
One of Wall Street’s legends did it all without touching a computer or accessing the internet.
Walter Schloss One of the most successful investors in history, Value Investor I know about the misuse of his investment.
(Market master:: Read other investment strategies and trading tips from market greats)
Born in August 1916, Schloss was not officially qualified and began working as a runner on Wall Street in 1934, after which he served in the United States Army Communications Corps.He finally Benjamin Graham After taking an investment course taught by Benjamin Graham on the New York Stock Exchange, he enrolled in a value investment school.
He then worked for Graham-Newman Partnership under Graham. Warren Buffett..
In 1955 he founded his own company, Walter J Schloss Associates, which set one of the best records in investment history until his death in 2012. It’s a record that’s hard to match with the best investors each year.
In 1984, Warren Buffett nominated Schloss as one of the great “supervisors”, saying: He just said that if the business was worth $ 1 and you could buy it for 40 cents, something good might happen to me. And he repeats it over and over again. He owns far more shares than I do and is less interested in the underlying nature of the business. It doesn’t seem to have much effect on Walter. That is one of his strengths. No one has a great influence on him. ”
Investment philosophy
Schloss was good at picking stocks when stocks reached new lows or when they were trading at a price lower than the book value per share. In addition to buying shares of companies below book value, he examined the company’s management to see if they were overly greedy or honest.
This information helped management know how they have been running their business over the years and was able to better predict whether the company’s business will prosper in the future.
Schloss thought it was better to buy stocks than bonds because of the potential for growth. He also limited holding one stake to less than 20% of the total portfolio. But at all times, he didn’t hesitate to hold up to 100 different stocks in his portfolio.
He weighted his holdings based on their perceived value and invested less in unconfident positions. He used limit orders to buy stocks and allow him to determine the price to pay.
Walter Schloss has left a library of investment wisdom relevant today.
According to Schloss, many investors like to predict and predict market directions and often run into serious problems. He said it should be recognized that it is almost impossible to time the market and make accurate forecasts.
“I’m not good at timing the market, so when people ask me what the market is doing, their guesses are the same as mine,” he said in the article.
Schloss said investors should not believe in the promises of the company’s management and should not trust earnings forecasts.
“I have nothing to oppose earnings, except that earnings can change in the first place. Second, your earnings forecasts may be correct, but people’s thinking about multiples It’s changed, so it’s easier and more satisfying to look at the book value. Revenues are much more likely to fluctuate than book values, so it’s important to estimate revenue over a longer period, such as next year. Errors can occur, “he said.
Schloss believed that weak emotional intelligence was deadly to an investor’s career. Investors with weak emotional intelligence will find it very difficult to take advantage of good opportunities to buy value stocks. Also, they cannot hold stocks when they fall.
“The ability to think emotionally and clearly in the field of investment is not an easy task. Fear and greed tend to influence one’s judgment. Have a strong stomach and are willing to accept unrealized losses. Must be, “he said.
Schloss said investors should learn to stay away from the daily hustle and bustle of the market. That way, you can control your emotions and make better investment decisions.
“I’m trying to get away from every day. I don’t have a ticker tape machine in my office. I try to stay in the emotions of the market. The market is a very emotional place and appeals to fear and horror. Greedy, all these unpleasant traits people have, “he said.
Schloss said it is important for investors to invest only in areas that they understand and are satisfied with.
“If you’re new and don’t have a basic understanding of the area you’re looking at, it’s probably best to learn more or find another investment before diving,” he said.
According to Schloss, one of the biggest challenges value investors face was not knowing when to sell. He found it very easy to determine which stocks were statistically cheaper and which stocks had the characteristic of outperforming, but it’s never easy to know when to sell. was.
He followed the general rule of thumb of aiming for a 50% profit on any stock before selling it. Sometimes it continued to rise after selling the stock, but he tried to suppress his emotions and stuck to his decision.
Schloss believed that if investors buy cheaper than value and hold it long enough, depressed companies can turn around and make decent profits. Investors thought they could buy more of the stock if the company’s fundamentals were sound.
“If you buy a depressed company, it won’t rise right after you buy it. Believe it. It will fall. So you have to wait a while for the company to turn around,” he said.
Schloss has created a checklist to consider first before buying shares in the company. Inventory must be owned-
Schloss says diversifying the portfolio is very important in the long run. He advised investors to limit their holdings of one share to less than 20% of the total portfolio. He also felt that investors could diversify their portfolio up to 100 shares.
Before investing in a company, Schloss also looked at the value characteristics of that company.
A company that has real assets and has little or no debt and provides a safety margin if the company is liquidated.
In a lecture on how to make money in the stock market for young investors and those who are not familiar with the process of value investing,
Schloss once came up with a 15-point guide:-
Schloss emphasized focusing on assets rather than profits, which require the ability to identify competitive advantages and thoroughly document the financial statements of companies that are difficult for most people to understand. Different from Warren Buffett’s investment style to investigate.
While many investors often invest in businesses based on annual returns, Schloss has proven that focusing on assets on the balance sheet is more likely to be successful. Schloss’s investment style is a challenging style that is still in use today.
Nov. 25, 2021
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Walter Schloss was one of the most successful investors of all times, but very few outside the close circuit of value investors know about his investment exploits.
Investors these days have the luxury of fast internet connections and a deluge of information to track potential stock drivers and make a quick profitable trade.
One Wall Street legend did it all without ever having touched a computer or accessing the internet.
Walter Schloss was one of the most successful investors of all times, but very few outside the close circuit of value investors know about his investment exploits.
Born in August 1916, Schloss had no formal qualifications and began working as a runner on Wall Street in 1934 before serving in the US Army Signal Corps. He eventually became a notable follower of the Benjamin Graham School of Value Investing, after he took investment courses taught by Benjamin Graham at the New York Stock Exchange Institute.
